Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 1.266


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX3chr5_+_1707362870.353.9e-01Click!
TLX1chr10_+_1028910600.186.6e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_58251715 2.517 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr1_-_153588789 2.195 NM_020672
S100A14
S100 calcium binding protein A14
chr1_-_242612757 1.864 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr1_-_153363544 1.737 NM_002964
S100A8
S100 calcium binding protein A8
chr18_-_74728677 1.485 MBP
myelin basic protein
chr11_-_71752099 1.185 NUMA1
nuclear mitotic apparatus protein 1
chr16_+_57662301 1.130 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr4_-_84255895 1.126 NM_001199830
HPSE
heparanase
chr22_-_39640956 1.100 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide
chr8_-_21988518 1.094 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr9_-_23821842 1.050 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr9_-_23821808 1.033 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_84256304 0.992 NM_001166498
NM_006665
HPSE

heparanase

chr10_+_82173574 0.967 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr15_-_83621350 0.965 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr6_-_39197225 0.961 NM_003740
KCNK5
potassium channel, subfamily K, member 5
chr19_-_49258646 0.958 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr4_-_84255999 0.956 HPSE
heparanase
chr19_-_36004553 0.951 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr21_+_46875402 0.916 NM_030582
COL18A1
collagen, type XVIII, alpha 1
chr12_-_8815370 0.897 NM_003480
MFAP5
microfibrillar associated protein 5
chr5_+_66124603 0.892 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr9_+_35673852 0.874 NM_001216
CA9
carbonic anhydrase IX
chr8_-_8239188 0.826 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr12_-_8815479 0.809 MFAP5
microfibrillar associated protein 5
chr15_-_59665069 0.807 NM_004998
MYO1E
myosin IE
chr4_-_84256012 0.804 NM_001098540
HPSE
heparanase
chr6_+_14117857 0.766 NM_001040280
NM_004233
CD83

CD83 molecule

chr15_-_59665053 0.765 MYO1E
myosin IE
chr15_+_40545348 0.739 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr15_+_89182038 0.710 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr9_-_23821477 0.707 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr16_+_57406398 0.681 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr20_+_9049660 0.676 NM_001172646
PLCB4
phospholipase C, beta 4
chr1_+_1981902 0.673 NM_002744
PRKCZ
protein kinase C, zeta
chr12_-_8815266 0.648 MFAP5
microfibrillar associated protein 5
chr2_+_69001932 0.647 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr6_+_14117486 0.638 NM_001251901
CD83
CD83 molecule
chr2_+_219187858 0.637 NM_022572
PNKD
paroxysmal nonkinesigenic dyskinesia
chrX_-_128788913 0.632 NM_017413
APLN
apelin
chr9_-_132515290 0.630 NM_004878
PTGES
prostaglandin E synthase
chr6_+_150920998 0.610 NM_001029884
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr8_-_80679897 0.602 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr11_+_5410606 0.600 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr7_-_16844606 0.600 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr1_+_43735664 0.597 NM_144626
TMEM125
transmembrane protein 125
chr7_+_26400503 0.581 NM_001199837
SNX10
sorting nexin 10
chr9_-_117554809 0.568 NM_001204344
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr11_+_1151578 0.567 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr22_+_45072687 0.554 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr17_-_74483806 0.550 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr22_+_40390935 0.548 NM_138435
FAM83F
family with sequence similarity 83, member F
chr2_+_219187975 0.543 PNKD
paroxysmal nonkinesigenic dyskinesia
chrX_+_99899162 0.522 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr4_-_103245468 0.522 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_+_48503607 0.519 ACSF2
acyl-CoA synthetase family member 2
chr17_-_76975932 0.508 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr17_+_48503518 0.500 NM_025149
ACSF2
acyl-CoA synthetase family member 2
chr1_+_153747767 0.499 NM_024330
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr2_-_74734498 0.490 PCGF1
polycomb group ring finger 1
chr1_+_95558072 0.486 NM_001199679
TMEM56
transmembrane protein 56
chr2_-_74734785 0.484 NM_032673
PCGF1
polycomb group ring finger 1
chr1_-_159915382 0.469 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr1_+_33231260 0.468 KIAA1522
KIAA1522
chr9_-_117156684 0.456 NM_030767
AKNA
AT-hook transcription factor
chr10_+_102758072 0.456 LZTS2
leucine zipper, putative tumor suppressor 2
chr7_-_37024664 0.453 NM_001039459
ELMO1
engulfment and cell motility 1
chr16_+_2867163 0.448 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr1_+_31886659 0.441 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr14_+_21525980 0.441 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr6_-_31745048 0.440 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr10_+_11865310 0.439 NM_153256
C10orf47
chromosome 10 open reading frame 47
chr17_-_39661803 0.435 NM_002274
NM_153490
KRT13

keratin 13

chr17_+_73553883 0.432 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr1_+_33231227 0.432 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr1_+_220701547 0.428 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr6_-_53013581 0.424 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr17_-_27948345 0.421 NM_032854
CORO6
coronin 6
chr16_+_2867227 0.411 PRSS21
protease, serine, 21 (testisin)
chr16_-_87903028 0.399 NM_003486
SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr5_-_176831385 0.398 F12
coagulation factor XII (Hageman factor)
chr18_-_24129084 0.395 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chr19_-_16045669 0.391 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr6_+_135502521 0.386 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_+_9648931 0.385 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr19_+_39279849 0.382 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr14_+_91580467 0.368 C14orf159
chromosome 14 open reading frame 159
chr1_-_32264215 0.368 SPOCD1
SPOC domain containing 1
chr3_+_48264836 0.365 NM_004345
CAMP
cathelicidin antimicrobial peptide
chrX_+_17653412 0.355 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr6_-_111927059 0.350 TRAF3IP2
TRAF3 interacting protein 2
chr17_+_73720775 0.349 NM_001005619
ITGB4
integrin, beta 4
chr4_-_103266396 0.349 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chrX_-_54824672 0.347 NM_198510
ITIH6
inter-alpha-trypsin inhibitor heavy chain family, member 6
chr1_+_220960038 0.344 NM_022746
MARC1
mitochondrial amidoxime reducing component 1
chr1_-_153538305 0.342 NM_005978
S100A2
S100 calcium binding protein A2
chr8_+_24772454 0.338 NM_001105541
NEFM
neurofilament, medium polypeptide
chr14_+_91580713 0.337 C14orf159
chromosome 14 open reading frame 159
chr14_-_81864726 0.336 NM_033104
STON2
stonin 2
chr1_-_39407449 0.334 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chrX_+_99899388 0.329 SRPX2
sushi-repeat containing protein, X-linked 2
chr14_+_85996454 0.329 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_+_26191732 0.326 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr11_-_65326129 0.325 LTBP3
latent transforming growth factor beta binding protein 3
chr16_-_30124829 0.323 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr16_+_57653649 0.322 GPR56
G protein-coupled receptor 56
chr15_+_45422130 0.322 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr17_-_4463816 0.318 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr6_-_30043547 0.310 NM_170769
NM_025236
RNF39

ring finger protein 39

chr2_+_185463235 0.309 ZNF804A
zinc finger protein 804A
chr3_-_12200339 0.308 TIMP4
TIMP metallopeptidase inhibitor 4
chr4_-_53617781 0.306 NM_001242690
NM_024534
ERVMER34-1

endogenous retrovirus group MER34, member 1

chr10_-_89577883 0.303 NM_032810
ATAD1
ATPase family, AAA domain containing 1
chr14_+_85996512 0.297 FLRT2
fibronectin leucine rich transmembrane protein 2
chrX_-_8700170 0.297 NM_000216
KAL1
Kallmann syndrome 1 sequence
chr17_+_37894212 0.295 GRB7
growth factor receptor-bound protein 7
chr2_+_185463437 0.290 ZNF804A
zinc finger protein 804A
chr2_+_185463092 0.289 NM_194250
ZNF804A
zinc finger protein 804A
chrX_-_32173585 0.288 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr5_-_150948504 0.285 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
chr1_+_32043745 0.284 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr5_+_148961035 0.282 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr4_+_153864134 0.281 NM_033393
FHDC1
FH2 domain containing 1
chr3_-_48471401 0.281 NM_001130082
PLXNB1
plexin B1
chr21_+_33784751 0.280 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr1_-_22263676 0.279 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr17_+_72439187 0.276 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr20_+_56725982 0.275 NM_178456
C20orf85
chromosome 20 open reading frame 85
chr15_+_40532034 0.274 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr2_+_182850550 0.273 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr7_-_27187367 0.272 NM_024014
HOXA6
homeobox A6
chr4_+_86749045 0.271 ARHGAP24
Rho GTPase activating protein 24
chr8_-_57233240 0.266 NM_138969
SDR16C5
short chain dehydrogenase/reductase family 16C, member 5
chr4_+_183245136 0.266 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr16_+_22019438 0.264 NM_001164579
C16orf52
chromosome 16 open reading frame 52
chr11_-_65325391 0.263 LTBP3
latent transforming growth factor beta binding protein 3
chr1_+_179262960 0.263 SOAT1
sterol O-acyltransferase 1
chr2_+_220325533 0.262 NM_001173476
SPEG
SPEG complex locus
chr1_-_160001529 0.260 PIGM
phosphatidylinositol glycan anchor biosynthesis, class M
chr3_+_190231839 0.259 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr2_-_74756815 0.259 AUP1
ancient ubiquitous protein 1
chr12_+_21168629 0.258 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr5_-_54281345 0.256 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr6_-_31550065 0.256 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr9_+_102584136 0.256 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr7_+_86273867 0.256 GRM3
glutamate receptor, metabotropic 3
chr1_-_23886284 0.254 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr19_+_10397642 0.254 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr10_-_123353330 0.247 NM_001144913
NM_001144914
FGFR2

fibroblast growth factor receptor 2

chr22_+_33196801 0.247 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr2_-_74756838 0.246 AUP1
ancient ubiquitous protein 1
chr5_-_176831183 0.246 F12
coagulation factor XII (Hageman factor)
chr11_-_10715160 0.245 MRVI1
murine retrovirus integration site 1 homolog
chr1_-_32264271 0.244 SPOCD1
SPOC domain containing 1
chr4_-_122302112 0.238 NM_198179
QRFPR
pyroglutamylated RFamide peptide receptor
chr19_-_39264144 0.238 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr6_+_132859426 0.238 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr19_+_15751706 0.236 NM_000896
NM_001199208
NM_001199209
CYP4F3


cytochrome P450, family 4, subfamily F, polypeptide 3


chr8_-_131028646 0.235 FAM49B
family with sequence similarity 49, member B
chr3_-_129599220 0.235 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr2_+_112812799 0.235 NM_032824
TMEM87B
transmembrane protein 87B
chr1_+_155023781 0.234 ADAM15
ADAM metallopeptidase domain 15
chr3_-_12200850 0.232 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr6_-_16761600 0.230 NM_000332
NM_001128164
ATXN1

ataxin 1

chr4_-_46391393 0.228 NM_001114175
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr12_-_25055966 0.227 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr1_+_111833473 0.226 NM_021797
NM_201653
CHIA

chitinase, acidic

chr11_-_65325632 0.225 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr1_+_117452359 0.224 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr20_-_44168128 0.221 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr3_-_14989616 0.216 LOC100505641
uncharacterized LOC100505641
chr6_-_111894897 0.215 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr1_+_179262936 0.215 SOAT1
sterol O-acyltransferase 1
chr17_-_42992852 0.215 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr3_+_14989076 0.214 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr17_-_3182267 0.212 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr11_-_57089670 0.212 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr17_+_7210929 0.212 EIF5A
eukaryotic translation initiation factor 5A
chr7_+_86274076 0.211 GRM3
glutamate receptor, metabotropic 3
chr6_-_3445198 0.210 NM_021945
SLC22A23
solute carrier family 22, member 23
chr6_+_123100860 0.209 FABP7
fatty acid binding protein 7, brain
chrX_-_138914384 0.208 NM_001010986
NM_173694
ATP11C

ATPase, class VI, type 11C

chr14_-_23445885 0.208 AJUBA
ajuba LIM protein
chr4_-_103265818 0.207 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr1_-_32281577 0.204 NM_144569
SPOCD1
SPOC domain containing 1
chr11_-_30607762 0.204 NM_001145399
MPPED2
metallophosphoesterase domain containing 2
chr19_+_50084586 0.202 NM_000951
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr17_+_40439564 0.200 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr9_-_98268866 0.200 PTCH1
patched 1
chr19_-_43969723 0.196 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr1_+_18434236 0.196 NM_032880
IGSF21
immunoglobin superfamily, member 21
chr1_+_84767288 0.195 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr1_+_86889768 0.194 NM_006536
CLCA2
chloride channel accessory 2
chr17_-_41910439 0.192 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr10_+_5454516 0.192 NM_001047160
NET1
neuroepithelial cell transforming 1
chr7_-_20256942 0.191 NM_182762
MACC1
metastasis associated in colon cancer 1
chr16_+_56899118 0.190 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr1_+_179262848 0.190 NM_001252511
NM_001252512
NM_003101
SOAT1


sterol O-acyltransferase 1


chr15_+_77287738 0.189 PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr20_+_42984338 0.189 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
18.48 1.85e-02 GO:0048755 branching morphogenesis of a nerve

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 2.85e-04 GO:0044459 plasma membrane part
1.62 2.03e-03 GO:0044421 extracellular region part
1.54 4.08e-03 GO:0031226 intrinsic to plasma membrane
1.53 5.42e-03 GO:0005887 integral to plasma membrane
1.64 1.22e-02 GO:0005624 membrane fraction
1.59 3.26e-02 GO:0005626 insoluble fraction

Nothing significant found in function category.